System identification of hunchback protein patterning in early Drosophila embryogenesis
Anil Aswani, Harendra Guturu, Claire Tomlin

Citation
Anil Aswani, Harendra Guturu, Claire Tomlin. "System identification of hunchback protein patterning in early Drosophila embryogenesis". Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference, 7723-7728, 18, December, 2009.

Abstract
Early patterning in the Drosophila melanogaster embryo occurs through a complicated network of interactions involving transcription factor proteins and the mRNA of their target genes. One such system is the pattern of hunchback mRNA and its regulation by Bicoid and Kr¨uppel proteins. This system is well-studied, but there is disagreement amongst biologists on how exactly hunchback expression is regulated. We attempt here to provide evidence to distinguish between two models in contention, through system identification. Our general approach is to do nonlinear regression on a parametric, nonlinear partial differential equation model which incorporates transcription, diffusion, and degradation. We perform the regression, analyze the results and then interpret the results in the biological context. We also compare our results to previous work on this system.

Electronic downloads

Internal. This publication has been marked by the author for Chess-only distribution, so electronic downloads are not available without logging in.

Citation formats

• HTML

  Anil Aswani, Harendra Guturu, Claire Tomlin. <a
  href="http://chess.eecs.berkeley.edu/pubs/606.html"
  >System identi�cation of hunchback protein
  patterning in early Drosophila embryogenesis</a>,
  Joint 48th IEEE Conference on Decision and Control and 28th
  Chinese Control Conference, 7723-7728, 18, December, 2009.

• Plain text

  Anil Aswani, Harendra Guturu, Claire Tomlin. "System
  identi�cation of hunchback protein patterning in
  early Drosophila embryogenesis". Joint 48th IEEE
  Conference on Decision and Control and 28th Chinese Control
  Conference, 7723-7728, 18, December, 2009.

• BibTeX

  @inproceedings{AswaniGuturuTomlin09_SystemIdenticationOfHunchbackProteinPatterningInEarly,
      author = {Anil Aswani and Harendra Guturu and Claire Tomlin},
      title = {System identi�cation of hunchback protein
                patterning in early Drosophila embryogenesis},
      booktitle = {Joint 48th IEEE Conference on Decision and Control
                and 28th Chinese Control Conference},
      pages = {7723-7728},
      day = {18},
      month = {December},
      year = {2009},
      abstract = {Early patterning in the Drosophila melanogaster
                embryo occurs through a complicated network of
                interactions involving transcription factor
                proteins and the mRNA of their target genes. One
                such system is the pattern of hunchback mRNA and
                its regulation by Bicoid and Kr¨uppel proteins.
                This system is well-studied, but there is
                disagreement amongst biologists on how exactly
                hunchback expression is regulated. We attempt here
                to provide evidence to distinguish between two
                models in contention, through system
                identification. Our general approach is to do
                nonlinear regression on a parametric, nonlinear
                partial differential equation model which
                incorporates transcription, diffusion, and
                degradation. We perform the regression, analyze
                the results and then interpret the results in the
                biological context. We also compare our results to
                previous work on this system.},
      URL = {http://chess.eecs.berkeley.edu/pubs/606.html}
  }
  

Posted by Anil Aswani on 17 Jun 2009.
For additional information, see the Publications FAQ or contact webmaster at chess eecs berkeley edu.